Best Known Treatments For Gout

                

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Gout therapy is two pronged:

? The management of acute gout attacks

? The prevention of further attacks and other related complications

Treatment of gout involves two distinct approaches

? Therapy for reducing inflammation

? Therapy for controlling hyperuricemia, which is a life-long commitment.

Drugs that are to be used to manage hyperuricemia depend on:

? The number of previous attacks ? drugs that lower urate levels should not be administered after a single gout attack. These should be used only after the second or the third attack.

? The presence of tophi ? tophaceous gout needs the administration of antihyperuricemics.

The first step of the therapy should be absolutely aimed at alleviating the immediate symptoms of the acute attack. Only after these are eradicated, treatment of hyperuricemia should be considered, if the condition is indicated. The condition can either be targeted at source, by preventing excessive formation of uric acid, or the elimination of the metabolite can also be beleaguered. The antihyperuricemic medicines should never be introduced at the time of an acute attack, because these have the potential to aggravate the symptoms and prolong the attack. Only when all signs of inflammation have resolved, reduction of urate concentrations in the blood should be aimed.

Treatment of Acute Gout

Non-steroidal anti-inflammatory drugs (NSAIDS), followed by Colchicine, are the medicines of choice in the treatment of acute cases of gout. Intramuscular injection of corticosteoids or adreno-corticotrophic hormones can effectively terminate a gout attack within 12 to 24 hours of application. Patients with renal troubles or intolerances to the other rugs are benefited by this mode of treatment.

Treatment of Chronic Gout

The goal of the therapy for chronic gout is to prevent the recurrence of gout attacks. The chief procedure is to ebb the uric acid levels in the blood. The types of medications used include:

? Xanthine Oxidase Inhibitors, as for example, allopurinol. These function by diminishing the amount of uric acid metabolized in the body.

? Uricosuric Agents, for instance, Probenecid or Sulfinpyrazone. These drugs act on the kidneys to aid elimination of the excess uric acid synthesized in the body.

Treatment of Tophaceous Gout

The underlying principle in the treatment of tophi is to lessen the level of plasma urate to such an extent that urate can be reabsorbed from the exterior of the tophi. Production of uric acid is made to be lesser than the amount excreted. This results in effective loss of uric acid from the blood. Development of kidney stones must be prevented as well.

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